Clomid - Clomiphene citrate clomid
Clomid - Clomiphene citrate clomid Clomid is not an anabolic/androgenic steroid.
Since it is a synthetic estrogen it belongs, however, to the group of sex
hormones. In school medicine Clomid is normally used to trigger ovulation.
Clomid, by setting in motion the process of releasing hormones, stimulates the
release of gonadotropin and triggers ovulation in women with anovulatory cycles
and who are sterile because of this. Although this is actually a drug destined
for women its effect on men is undisputed. The manufacturer of Dyneric,the
Merrell Dow Pharma GmbH, writes in its package insert for the German version of
Clomid: "Dyneric causes an improved activity between mid-brain, pituitary gland,
and ovaries." What however is not mentioned is that Dyneric also improves the
activity between mid-brain (hypothalamus), pituitary gland thypophysis), and
testes in men. Clomid has a strong influence on the hypothalamohypophysial
testicular axis. It stimulates the hypophysis to release more gonadotropin so
that a faster and higher release of FSH (follicle stimulating hormone) aud LH
(luteinizing hormone) occurs. This results in an elevated endogenous (body's own
testosterone level. Clomid is especially effective when the body's own
testosterone production, due to the intake of anabolic/androgenic steroids, is
suppressed. In most cases Clomid can normalize the testosterone level and the
spermatogenesis (sperm development)within 10-14 days. For this reason Clomid is
primarily taken after steroids are discontinued. At this time it is extremely
important to bring the testosterone production to a normal level as quickly as
possible so that the loss of strength and muscle mass is minimized. Even better
results can be achieved if Clomid is combined with HCG or when Clomid is used
after the intake of HCG. The difference between Clomid and HCG lies in the fact
that Clomid has a direct influence on the hypothalamus and the hypophysis, thus
regenerating the entire regulating cycle while HCG imitates the effect of the
luteinizing hormone (LH) which stimulates the Ledig's cells fo produce more
testosterone. Since HCG, unlike Clomid, leads to a distinctly elevated
plasmatestosterone level within a few hours, many athlets first take HCG and
then Clomid (see also HCG). Paradoxically, although Clomid is a synthetic
estrogen it also works as an antiestrogen. The reason is that Clomid has only a
very low estrogenic effect and thus the stronger estrogens which, for example
form during the aromatization of steroids, are blocked at the receptors. These
would include those that develop during the aromatizing of steroids. This does
not prevent the steroids from aromatizing but the increased estrogen is mostly
deactivated since it cannot attach to the receptors. The inereased water
retention and the possible signs of feminization can thus be reduced or even
completely avoided. Since the antiestrogenic effect of Clomid is lower than
those found in Proviron, Nolvadex, and Teslac it is mainly taken as a
testosterone stimulant. From the German book Doping By Brigitte Berendonk the
reader can learn that Clomid is not only used in bodybuilding: "During the
1980's Clomiphene (table 2) has been used, a medication that promotes the
production of the body's own stimulating hormone, gonadotropin, which in turn
increases the testosterone level. - It is, for example, administered to women as
a so-called antiestrogen to trigger ovulation ("ovulation
stimulator").Clomiphene (usually the Hungarian compound Clostilbegyt) was used
by rowers (resp. Prof. Dr. Herbert Gurtler) and weightlifers (Dr Lathan; p. 187)
since the late 1970's. Increasingly, it was used in other sports disciplines as
well, including track and field athletics. Riedel, at the time, happily made the
handwritten entry in his notebook: "Substance that is not an anabolic: generally
traceable but is not a doping substance." The dosages were horrendous. I found
entries of up to l5 times 100mg daily and the report that the positive effect
lasts up to 20 days after the last tablet is taken. And it was already assured
since 1982 that the increased testosterone production after doping with
Clomiphene did not reveal traits of the T/E quotient
(testosterone/epitestosterone quotient, the author)during doping tests. Side
effects of Clomid are very rare if reasonable dosages are taken. Possible side
effects are climacteric hot flashes and occasional visual disturbances which can
manifest themselves in blurred vision, giving flickering or flashing. Should
visual distuibances occur, the manufacturer recommends discontinuing Clomid
treatment. Inadequate liver functions cannot be excluded;however,they are very
unlikely in women enlargement of the ovaries and abdominal pain can occur since
Clomid stimulates the ovaries. When taking Clomid multiple pregnancies are
possible as well. As for the dosage, 50-100 mg/per day(1-2 tablets) seems to be
sufficient. The tablets are usually taken with fluids after meals. If several
tablets are taken it is recomended that they be administered in equal doses
distributed throughout the day. The duration of intake should not exceed 10 to
14 days. Most athlets begin with 100 mg/day taking one 50mg tablet every morning
and evening after meals. After the fifth day the dosage is often reduced to only
one 50mg tablet per day. It is normally not necessary to take the compound for
more than 10 days in order to increase the endogenus testosterone production.
Since Clomid should not be taken for a prolonged time its application as an
antiestrogen must be excluded because, for that purpose, it would have to be
taken for several weeks. Clomid is relatively expensive. A package with 10
tablets costs approx. $35 - 45 on the black market. Fortunately, since the
intake is only for a brief time, the financial burden usually becomes
acceptable. The foreign compounds such as the Spanish Omifin are considerably
cheaper and cost less than $2 per tablet.
by Bill Roberts - Clomid is the anti-estrogen of choice for improving recovery of
natural testosterone production after a cycle, improving testosterone production
of endurance athletes, and is also effective in reducing risk of gynecomastia
during a cycle employing aromatizable steroids. While it has been claimed that
Clomid "stimulates" production of LH and therefore of testosterone, in fact
Clomids activity is achieved not by stimulation of the hypothalamus and
pituitary, but by blocking their inhibition by estrogen. Clomid is a mixed
estrogen agonist/antagonist (activator/blocker) which, when bound to the
estrogen receptor, puts it in a somewhat different conformation (shape) than
does estradiol. The estrogen receptor requires binding of an estrogen or drug at
its binding site and also the binding of any of several cofactors at different
sites. Without the binding of the cofactor, the estrogen receptor is inactive.
Different tissues use different cofactors. Some of these cofactors are able to
bind to the estrogen receptor/Clomid complex, but others are blocked due to the
change in shape. The result is that in some tissues Clomid acts as an antagonist
-- the cofactor used in that tissue cannott bind and so the receptor remains
inactive -- and in others Clomid acts as an agonist (activator), because the
cofactors used in that tissue are able to bind. Clomid is an effective
antagonist in the hypothalamus and in breast tissue. It is an effective agonist
in bone tissue, and for improving blood cholesterol. Clomid also has the
property of reducing the adverse effect of exercise-induced damage of muscle
tissue. This is very significant for endurance athletes but is not very
significant, if at all significant, with reasonable weight training. Clomid does
not perceptibly affect gains of the weight trainer either favorably or adversely
in my experience. The drug seems to have estrogenic effects on mood, which can
be beneficial (improving relationships with women by improving empathy) or can
yield depression or PMS-like symptoms, but for most users there is no
significant effect either way. The claim that duration of intake should not
exceed 10-14 days is incorrect. Clinical studies with male patients have been
for periods of a year or longer. This error probably originates from the fact
that, for use in women, due to the menstrual cycle there would obviously be no
point in trying to stimulate ovulation all four weeks of the month. Thus, use in
women is limited to 10-14 days. That limitation is not because of toxicity.
Clomid is in fact useful throughout a cycle if aromatizable drugs are being
used. I do think however that to be conservative, one should use it no more than
2/3 of the time throughout the year or a little less. Product Information
Courtesy Pharma Group Product Name: CLOMIFEN International Name: Clomid
Contents: 25 mg Delivery: 20 caps Manufacturer: Casen Pharmacy
Active Substances: Clomiphene Citrate.